Affinity maturation is often a necessary step for the development of potent therapeutic molecules.Many different diversification strategies have been used for antibody affinity maturation, including error-prone PCR, chain shuffling, and targeted complementary-determining region (CDR) mutation.Although effective, they can negatively impact antibody
We propose a simple approach to investigate the spreading of news in a network.In Camp Furniture more detail, we consider two different versions of a single type of information, one of which is close to the essence of the information (and we call it good news), and another of which is somehow modified from some biased agent of the system (fake news
Patient-derived organoids (PDOs) represent a cutting-edge Knife Sharpening Steels approach in cancer research that holds significant promise for revolutionizing various aspects of oncology.These three-dimensional structures, cultivated from patient tumor samples, faithfully mimic the intricate cellular composition and architecture of the original t
For more than a year now, Trinket severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been causing the coronavirus disease (COVID-19) pandemic with high mortality and detrimental effects on society, economy, and individual lives.Great hopes are being placed on vaccination as one of the most potent escape strategies from the pandemic an
Abstract Background MiRNA are about 22nt long small noncoding RNAs that post transcriptionally regulate gene expression in animals, plants and protozoa.Confident MIXED VEGETABLES identification of MiRNA-Target Interactions (MTI) is vital to understand their function.Currently, several integrated computational programs and databases are available fo